AMD Ryzen Threadripper PRO 3995WX vs AMD EPYC 7543

Updated Nov 2026 · Scored by the Let’s Compare Data Engine · How we score

For most buyers the AMD Ryzen Threadripper PRO 3995WX is the better pick — it scores 78/100 to the AMD EPYC 7543's 70, leading on Core Specifications and Benchmark. Choose the AMD EPYC 7543 instead if you want to spend less.

Verdict

Our overall take, at a glance

AMD Ryzen Threadripper PRO 3995WX leads overall

AMD Ryzen Threadripper PRO 3995WX

AMD EPYC 7543

Why it stands out

Core Specifications L1 Cache: 4,096 KB (100% more)
Core Specifications L2 Cache: 32 MB (100% more)
Core Specifications Cores: 64

Winner by category for AMD Ryzen Threadripper PRO 3995WX vs AMD EPYC 7543
Category	AMD Ryzen Threadripper PRO 3995WX	AMD EPYC 7543	Winner
Core Specifications	57	52	AMD Ryzen Threadripper PRO 3995WX
Integrated Graphics	0	0	Tie
Benchmark	89	79	AMD Ryzen Threadripper PRO 3995WX

In-depth analysisAI

AI-generated from the cited sources — may be incomplete or inaccurate; verify important details before deciding · generated Nov 2026.

AMD Ryzen Threadripper PRO 3995WX

AMD Ryzen microprocessors are x86-64 CPUs based on the Zen microarchitecture. The Ryzen family includes various processor lines such as Ryzen 3, Ryzen 5, and Ryzen Threadripper, which can feature up to 96 cores. Desktop processors include different generations like the Ryzen 1000, 2000, 3000, 4000, etc., series.

Best for N/A

Pros

Cons

AMD EPYC 7543

The AMD EPYC 7543 is a 32-core, 64-thread server processor built on a 7nm manufacturing process, engineered for enterprise data centers and heavy server workloads. It features a base clock frequency of 2.8 GHz, a maximum boost clock of 3.7 GHz, and a substantial 256 MB of L3 cache. Designed around a 225W base power envelope, it targets high-density virtualization and compute-intensive enterprise applications.

Best for Enterprise server virtualization and cloud infrastructure deploymentBest for Memory-bound server applications benefiting from expansive L3 cache

Pros

32 cores and 64 threads offer high multi-threaded compute density
Large 256 MB L3 cache helps mitigate memory bottlenecks in data-heavy tasks
Strong multi-core output demonstrated by a PassMark CPU Mark score over 60,000

Cons

High 225W base power draw (up to 240W max) demands robust thermal management
No integrated graphics onboard
Multiplier is locked, preventing hardware clock adjustments

Value for Money

Which is the better deal for the price

Pre-filled with launch prices where known — enter today's price for an up-to-date check. Use the same currency for both.

AMD Ryzen Threadripper PRO 3995WX

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AMD EPYC 7543

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Performance

Higher benchmark score = faster

AMD Ryzen Threadripper PRO 3995WX82,018

AMD EPYC 754360,960

See the raw benchmark values →

Benchmark score — a measured indicator of raw performance, not a guarantee of real-world speed.

Review Videos

Hand-picked expert reviews for each product

Detailed Specifications

The full spec sheet, side by side

Core Specifications

Feature	AMD Ryzen Threadripper PRO 3995WX	AMD EPYC 7543
Cores	64	32
Threads	128	64
Base Frequency	2.7 GHz	2.8 GHz4% more
Base Power Consumption	280 W24% more	225 W
Maximum Frequency	4.2 GHz14% more	3.7 GHz
Maximum Power Consumption	N/A	240 W
L1 Cache	4,096 KB100% more	2,048 KB
L2 Cache	32 MB100% more	16 MB
L3 Cache	256 MB	256 MB
Lithography Process	7 nm	7 nm
Is unlocked	No	N/A

Integrated Graphics

Feature	AMD Ryzen Threadripper PRO 3995WX	AMD EPYC 7543
Model	N/A	N/A

Benchmark

Feature	AMD Ryzen Threadripper PRO 3995WX	AMD EPYC 7543
PassMark CPU Mark	82,01835% more	60,960

Specification Note

Specifications are compiled from official manufacturer data and other reliable internet sources. Some features may vary by region or model configuration.

Frequently Asked Questions

Common questions about AMD Ryzen Threadripper PRO 3995WX vs AMD EPYC 7543 comparison

Based on our overall comparison score, AMD Ryzen Threadripper PRO 3995WX rates higher at 88/100 versus 83/100 for AMD EPYC 7543 — a 5-point lead. AMD Ryzen Threadripper PRO 3995WX is the stronger overall pick, though the right choice still depends on which specs matter most to you; the full spec table above breaks down every difference.

AMD Ryzen Threadripper PRO 3995WX and AMD EPYC 7543 are compared side by side above across every spec in the cpus category — including performance, features and design — each scored 0–100 so you can see exactly where one leads the other. Our overall scores are 88/100 for AMD Ryzen Threadripper PRO 3995WX and 83/100 for AMD EPYC 7543.

If you want the higher-rated cpus option overall, AMD Ryzen Threadripper PRO 3995WX (88/100) edges out AMD EPYC 7543 (83/100). But if AMD EPYC 7543 is cheaper or stronger on the specific specs you care about, it can still be the better buy — use the spec table and strengths profile above to decide.